ANTIFERTILITAS KULIT BUAH SEMANGKA (Citrullus lanatus) PADA MENCIT JANTAN (Mus Musculus)

    Aditya Rizky Fauzi, - (2023) ANTIFERTILITAS KULIT BUAH SEMANGKA (Citrullus lanatus) PADA MENCIT JANTAN (Mus Musculus). S1 thesis, Universitas Pendidikan Indonesia.

    Abstract

    Fertilitas merupakan kemampuan individu atau populasi untuk menghasilkan keturunan. Fertilitas dapat
    terjadi ketika kualitas sperma yang dihasilkan baik. Kualitas sperma dapat dilihat dari jumlah sperma,
    morfologi sperma, dan juga motilitas sperma. Lapisan kulit semangka memiliki banyak sekali senyawa
    aktif, diantaranya flavonoid, alkaloid, tannin, saponin dan steroid. Senyawa-senyawa seperti saponin,
    tanin, flavonoid, dan alkaloid yang terdapat pada kulit semangka ini dapat mengurangi tingkat kesuburan
    dengan cara mengganggu fungsi reproduksi. Penelitian ini dilakukan dengan tujuan untuk mengetahui
    potensi kulit semangka (Citrullus lanatus) sebagai antifertilitas pada mencit jantan. Sebanyak 24 ekor
    mencit (Mus musculus) jantan dikelompokkan menjadi enam kelompok perlakuan yaitu kelompok
    kontrol (diberi akuades), kelompok perlakuan P1 (ekstrak kulit semangka 140mg/kgBB), kelompok
    perlakuan P2 (ekstrak kulit semangka 280mg/kgBB), kelompok perlakuan P3 (ekstrak kulit semangka
    420mg/kgBB), kelompok perlakuan P4 (ekstrak kulit semangka 560mg/kgBB) dan kelompok perlakuan
    P5 (ekstrak kulit semangka 700mg/kgBB). Hasil penelitian dianalisis menggunakan One Way ANOVA
    dan dilanjutkan uji Post Hoc Tukey. Ekstrak kulit semangka tidak berpengaruh terhadap berat badan
    mencit, tetapi dapat menurunkan bobot testis dan menurunkan kualitas sperma seperti menurunkan
    jumlah sperma yang dihasilkan, mengurangi jumlah sperma normal dan meningkatkan jumlah sperma
    abnormal, dan mengurangi motilitas sperma. Hasil tersebut membuktikan bahwa perlakuak P5 (ekstrak
    kulit semangka 700mg/kgBB) berpotensi sebagai antifertilitas.
    Fertility is the ability of an individual or a population to produce offspring. Fertility can occur when the
    quality of the produced sperm is good. Sperm quality can be observed based on the quantity of sperm,
    sperm morphology, and sperm motility. Watermelon rind contains a variety of active compounds,
    including flavonoids, alkaloids, tannins, saponins, and steroids. Compounds such as saponins, tannins,
    flavonoids, and alkaloids found in watermelon rind can reduce fertility levels by disrupting reproductive
    functions. This research aims to determine the potential of watermelon (Citrullus lanatus) rind as an
    antifertility agent in male mice. A total of 24 male mice (Mus musculus) were divided into six treatment
    groups: control group (given distilled water), treatment group P1 (watermelon rind extract at
    140mg/kgBW), treatment group P2 (watermelon rind extract at 280mg/kgBW), treatment group P3
    (watermelon rind extract at 420mg/kgBW), treatment group P4 (watermelon rind extract at
    560mg/kgBW), and treatment group P5 (watermelon rind extract at 700mg/kgBW). The research results
    were analyzed using One Way ANOVA and followed by Tukey's Post Hoc test. The watermelon rind
    extract did not affect the body weight of the mice, but it decreased testis weight and sperm quality by
    reducing the quantity of produced sperm, decreasing the number of normal sperm, increasing the number
    of abnormal sperm, and reducing sperm motility. These findings demonstrate that treatment group P5
    (watermelon rind extract at 700mg/kgBW) has potential as an antifertility agent

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    Official URL: http://repository.upi.edu/
    Item Type: Thesis (S1)
    Additional Information: https://scholar.google.com/citations?view_op=new_profile&hl=id&authuser=2 ID SINTA Dosen Pembimbing: Hernawati: 6005188 Yayan Sanjaya: 5978995
    Uncontrolled Keywords: Antifertilitas, Dosis, Kandungan ekstrak kulit semangka, Mencit Anti-fertility, Dosage, Watermelon peel extract content, Mice
    Subjects: L Education > L Education (General)
    Q Science > QH Natural history
    Q Science > QH Natural history > QH301 Biology
    Divisions: Fakultas Pendidikan Matematika dan Ilmu Pengetahuan Alam > Program Studi Biologi - S1 > Program Studi Biologi (non kependidikan)
    Depositing User: Aditya Rizky Fauzi
    Date Deposited: 18 Sep 2023 03:24
    Last Modified: 18 Sep 2023 03:24
    URI: http://repository.upi.edu/id/eprint/106216

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