eprintid: 137212 rev_number: 66 eprint_status: archive userid: 217392 dir: disk0/00/13/72/12 datestamp: 2025-09-16 01:32:51 lastmod: 2025-09-16 01:32:51 status_changed: 2025-09-16 01:32:51 type: thesis metadata_visibility: show creators_name: Laras Adistya Putri, - creators_name: Iqbal Musthapa, - creators_name: Vidia Afina Nuraini, - creators_nim: NIM2103259 creators_nim: NIDN0023127503 creators_nim: NIDN0005079302 creators_id: larasadistya@upi.edu creators_id: iqbalm@upi.edu creators_id: v.nuraini@upi.edu contributors_type: http://www.loc.gov/loc.terms/relators/THS contributors_type: http://www.loc.gov/loc.terms/relators/THS contributors_name: Iqbal Musthapa, - contributors_name: Vidia Afina Nuraini, - contributors_nidn: NIDN0023127503 contributors_nidn: NIDN0005079302 contributors_id: iqbalm@upi.edu contributors_id: v.nuraini@upi.edu title: ISOLASI DAN KARAKTERISASI FLAVONOID TERISOPRENILASI DARI AKAR Artocarpus heterophyllus SEBAGAI INHIBITOR ASETILKOLINESTERASE: Pengujian Potensi In Silico ispublished: pub subjects: QD divisions: KM full_text_status: restricted keywords: Akar nangka, alzheimer, asetilkolinesterase, flavonoid, licoflavone C Acetylcholinesterase, Alzheimer's disease, flavonoids, jackfruit’s root, licoflavone C note: https://scholar.google.com/citations?view_op=list_works&hl=en&user=gvJCRJ4AAAAJ ID SINTA Dosen Pembimbing: Iqbal Musthapa: 0023127503 Vidia Afina Nuraini: 0005079302 abstract: Tumbuhan Artocarpus heterophyllus, atau nangka, merupakan tumbuhan yang memiliki berbagai senyawa dengan potensi biologis seperti flavonoid, prenilflavonoid, sterol, stilbenoid, polifenol, dan terpenoid yang telah dilaporkan memiliki aktivitas antioksidan, antiinflamasi, antibakteri, antikanker, antikariogenik, dan antijamur. Penelitian ini bertujuan untuk mengisolasi dan mengkarakterisasi senyawa turunan flavonoid dari akar tumbuhan nangka, serta menguji aktivitas antialzheimer secara in silico. Tahap isolasi dilakukan dengan ekstraksi, fraksinasi, dan pemurnian menggunakan berbagai teknik kromatografi, yaitu Kromatografi Cair Vakum (KCV), Kromatografi Kolom Gravitasi (KKG), dan Kromatografi Lapis Tipis (KLT). Dari tahap pemisahan dan pemurnian, dihasilkan 1 isolat berupa padatan coklat kemerahan sebanyak 29,7 mg. Karakterisasi struktur senyawa yang diperoleh didasarkan pada data spektroskopi Nuclear Magnetic Resonance (NMR) 1D (1H-NMR) dan membandingkannya dengan literatur. Hasil dari karakterisasi tersebut menunjukkan senyawa isolat 1 memiliki struktur yang serupa dengan senyawa Licoflavone C. Uji aktivitas secara in silico dengan aplikasi BIOVIA Discovery Studio Visualizer dan AutoDock Tools menunjukkan bahwa senyawa licoflavone C memiliki aktivitas yang lemah untuk dijadikan sebagai kandidat obat antialzheimer dalam menggantikan donepezil melalui mekanisme penghambatan asetilkolinesterase. Artocarpus heterophyllus, or jackfruit, is a plant that has various compounds with biological potential such as flavonoids, prenylflavonoids, sterols, stilbenoids, polyphenols, and terpenoids that have been reported to have antioxidant, anti-inflammatory, antibacterial, anticancer, anticariogenic, and antifungal activities. This research aims to isolate and characterize flavonoid-derived compounds from jackfruit roots, as well as to test their anti-Alzheimer activity with in silico method. The isolation stage was carried out by extraction, fractionation, and purification using various chromatographic techniques, such as Vacuum Liquid Chromatography (VLC), Gravity Column Chromatography (GCC), and Thin Layer Chromatography (TLC). From the separation and purification stages, isolate 1 was produced in the form of a reddish-brown solid was obtained, weighing 29.7 mg. The structural characterization of the compound obtained was based on 1D Nuclear Magnetic Resonance (NMR) spectroscopy data (1H-NMR) and comparing it with the literature. The result of the characterization showed that isolate 1 compound has a similar structure to the Licoflavone C compound. In silico activity test using the BIOVIA Discovery Studio Visualizer and AutoDock Tools applications showed that the licoflavone C compound has weak activity to be used as a candidate of anti-Alzheimer's drug to replace donepezil through the acetylcholinesterase inhibition mechanism. date: 2025-08-13 date_type: published institution: Universitas Pendidikan Indonesia department: KODEPRODI47201#Kimia_S1 thesis_type: other thesis_name: other official_url: https://repository.upi.edu/ related_url_url: https://perpustakaan.upi.edu/ related_url_type: org citation: Laras Adistya Putri, - and Iqbal Musthapa, - and Vidia Afina Nuraini, - (2025) ISOLASI DAN KARAKTERISASI FLAVONOID TERISOPRENILASI DARI AKAR Artocarpus heterophyllus SEBAGAI INHIBITOR ASETILKOLINESTERASE: Pengujian Potensi In Silico. S1 thesis, Universitas Pendidikan Indonesia. document_url: http://repository.upi.edu/137212/1/S_KIM_2103259_Title.pdf document_url: http://repository.upi.edu/137212/2/S_KIM_2103259_Chapter1.pdf document_url: http://repository.upi.edu/137212/3/S_KIM_2103259_Chapter2.pdf document_url: http://repository.upi.edu/137212/4/S_KIM_2103259_Chapter3.pdf document_url: http://repository.upi.edu/137212/5/S_KIM_2103259_Chapter4.pdf document_url: http://repository.upi.edu/137212/6/S_KIM_2103259_Chapter5.pdf document_url: http://repository.upi.edu/137212/7/S_KIM_2103259_Appendix.pdf