AKTIVITAS ANTI INFLAMASI EKSTRAK BUAH JAMBU BIJI (Psidium guajava) PADA TIKUS MODEL Acute Respiratory Distress Syndrome (ARDS) YANG DIINDUKSI DENGAN LIPOPOLISAKARIDA (LPS)

Amanah Muthmainnah Idris, - (2021) AKTIVITAS ANTI INFLAMASI EKSTRAK BUAH JAMBU BIJI (Psidium guajava) PADA TIKUS MODEL Acute Respiratory Distress Syndrome (ARDS) YANG DIINDUKSI DENGAN LIPOPOLISAKARIDA (LPS). S1 thesis, Universitas Pendidikan Indonesia.

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Abstract

Acute Respiratory Distress Syndrome is one of the highest causes of death in COVID-19 patients. ARDS is an acute respiratory failure caused by buildup of fluid in the lungs, resulting in inflammation. Lungs damage triggers the generation of various proinflammatory cytokines such as tumor necrosis factor-alpha (TNF-α ) and interleukin 1 beta (IL-1β). LPS induction in rat is the most commonly used model to assess the inflammatory response, including increased levels of cytokines TNF-α and IL-1β. Guava (Psidium guajava L.) has a high content of important antioxidants, anti-viral, and anti-inflammatory activities. The purpose of this study was to determine anti inflammatory activity of guava extract of LPS-induced rats as ARDS model. Pretreatment of guava extract has been given for 28 days to improve rats immune system, than induced by LPS 5 μg/g BW as ARDS animal model. The extract was continued for 14 days, then rats were sacrificed and the inflammatory markers both serum and lung were measured by ELISA method. LPS induction increased TNF-α concentration of 438.35 pg/mL (serum), 10.7 pg/mg (lung), IL-1β concentration of 202.44 pg/mL (serum), and 4.99 pg/mg (lung). Giving various doses of guava extract 50; 400; 800 mg/Kg BW decreased TNF-α and IL-1β concentration in serum and lung significantly (p<0,05). The lowest concentration of TNF-α was 199.87 pg/mL (serum) and 5.77 pg/mg (lung) wich caused by dose 400 mg/Kg. The lowest concentration of IL-1β was 92.21pg/mL (serum) and 1.95 pg/mg (lung) wich caused by dose 800 mg/Kg. Guava extract showed anti-inflammatory activity in LPS-induced ARDS rat.

Item Type: Thesis (S1)
Uncontrolled Keywords: Guava, ARDS, Lipopolysaccharide, Inflammation Cytokine
Subjects: Q Science > QH Natural history > QH301 Biology
Q Science > QR Microbiology > QR180 Immunology
R Medicine > R Medicine (General)
Divisions: Fakultas Pendidikan Matematika dan Ilmu Pengetahuan Alam > Jurusan Pendidikan Biologi > Program Studi Biologi (non kependidikan)
Depositing User: Amanah Muthmainnah Idris
Date Deposited: 02 Sep 2021 06:13
Last Modified: 02 Sep 2021 06:13
URI: http://repository.upi.edu/id/eprint/65292

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