OVERVIEW PENGGUNAAN ENKAPSULASI SELULOSA NANOPARTIKEL PADA NANO MEDICINE

Yulia Guniawaty, - (2021) OVERVIEW PENGGUNAAN ENKAPSULASI SELULOSA NANOPARTIKEL PADA NANO MEDICINE. S1 thesis, Universitas Pendidikan Indonesia.

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Official URL: http://repository.upi.edu/

Abstract

ABSTRAK Enkapsulasi digunakan untuk menyalut senyawa obat sehingga dapat berfungsi sebagai penghantar obat (drug delivery) dan pelindung senyawa obat dari kerusakan. Nanoselulosa sebagai enkapsulan diperoleh dari hidrolisis selulosa. Nanoselulosa memiliki biokompatibilitas baik, biodegradable, non-toksik bermanfaat untuk sistem penghantaran obat yang baik. Penelitian ini merupakan literature review dengan model narrative dari 6 artikel terindeks scopus Q1-Q2 yang terbit pada 2016-2020. Studi ini dilakukan untuk mengetahui kondisi preparasi nanoselulosa, karakteristik, efisiensi dan drug release (pelepasan) senyawa obat yang di enkapsulasi menggunakan nanoselulosa. Hasil riset menunjukkan bahwa preparasi nanoselulosa dapat diperoleh dari berbagai sumber selulosa melalui cara kimia (hidrolisis) maupun mekanik yang menghasilkan nanoselulosa berukuran 2-70 nm dengan morfologi berbentuk oval dan bulat. Proses preparasi berbagai nanomedicine melalui enkapsulasi senyawa obat menggunakan nanoselulosa berlangsung pada suhu ruangan selama 1-6 jam. Hasil enkapsulasi nanoselulosa menghasilkan produk dengan morfologi batang berpori dengan persentase swelling 150-750%. Efisiensi enkapsulasi bervariasi dari 41-87,6%. Hasil uji drug release menunjukkan bahwa persentase pelepasan maksimum senyawa obat berkisar 66-90 %, dalam waktu pelepasan maksimum obat berkisar 10–14 jam. Kata kunci: selulosa, nanopartikel, nanoselulosa, enkapsulasi, nano medicine. ABSTRACT Encapsulation is used to coat drug compounds so that they can function as drug delivery and can reduce damage to the drug compounds. As an encapsulant, nanocellulose can be used which can be obtained from the hydrolysis of cellulose. Nanocellulose has good biocompatibility, biodegradable, non-toxic and is useful for good drug delivery systems. This research is a literature review with a narrative model from 6 Scopus Q1-Q2 indexed articles published in 2016-2020. This study was conducted to determine the condition of nanocellulose preparation, characteristics, efficiency and test results of drug release (release) of drug compounds encapsulated using nanocellulose. The results showed that the preparation of nanocellulose can be obtained from various sources of cellulose through chemical (hydrolysis) and mechanical methods which produce nanocellulose measuring 2-70 nm with oval and round morphology. The process of preparation of various nanomedicines through encapsulation of drug compounds using nanocellulose takes place at room temperature for 1-6 hours. The results of the encapsulation of nanocellulose resulted in a product with a porous stem morphology with a swelling percentage of 150-750%. Encapsulation efficiency varies from 41-87.6%. The results of the drug release test showed that the percentage of maximum release of drug compounds ranged from 66-90%, within the maximum release time of 10-14 hours. Keywords: cellulose, nanoparticles, nanocellulose, encapsulation, nano medicine

Item Type: Thesis (S1)
Uncontrolled Keywords: cellulose, nanoparticles, nanocellulose, encapsulation, nanomedicine
Subjects: L Education > L Education (General)
Q Science > QD Chemistry
Divisions: Fakultas Pendidikan Matematika dan Ilmu Pengetahuan Alam > Jurusan Pendidikan Kimia > Program Studi Kimia (non kependidikan)
Depositing User: Yulia Guniawaty
Date Deposited: 27 Aug 2021 05:46
Last Modified: 27 Aug 2021 05:46
URI: http://repository.upi.edu/id/eprint/64363

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