Lucky Angkawidjaja Roring, - (2024) PERBEDAAN PENGARUH AKTIVITAS DI RUANG TERBUKA DAN RUANG TERBUKA BERPOLUSI SERTA PEMBERIAN ANTIOKSIDAN TERHADAP INFLAMASI DAN MITOCHONDRIAL BIOGENESIS PARU-PARU. S3 thesis, Universitas Pendidikan Indonesia.
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Abstract
ABSTRAK Penelitian dilatarbelakangi oleh pentingnya aktivitas di ruang terbuka sebagai salah satu upaya memelihara dan meningkatkan kesehatan. Aktivitas di ruang terbuka khususnya di area perkotaan memiliki risiko yang ditimbulkan oleh polusi udara. Pemberian antioksidan diharapkan dapat memiliki pengaruh terhadap inflamasi dan mitochondrial biogenesis paru-paru sebagai akibat paparan polusi udara. Tujuan penelitian adalah menguji perbedaan pengaruh aktivitas di ruang terbuka dan ruang terbuka berpolusi serta pemberian antioksidan terhadap proses inflamasi dan mitochondrial biogenesis paru-paru. Penelitian menggunakan pendekatan kuantitatif dengan metode eksperimen dan desain True Experimental serta Randomized Posttest-only Control Group Design. Subjek penelitian menggunakan tikus jantan galur Wistar berusia 8 – 12 minggu. Hasil penelitian menunjukkan: 1) Aktivitas berpengaruh signifikan terhadap IL-6 tetapi tidak signifikan terhadap NF-κB jaringan paru-paru; 2) Aktivitas juga berpengaruh signifikan terhadap biomaker mitochondrial biogenesis PGC-1α dan TOM20, namun tidak berpengaruh signifikan terhadap COXIV; 3) Polusi udara secara parsial tidak berpengaruh signifikan terhadap IL-6 dan NF-κB, namun ketika berinteraksi dengan pemberian ekstrak daun Moringa oleifera, polusi berpengaruh signifikan terhadap IL-6 jaringan paru-paru; 4) Secara parsial, polusi berpengaruh signifkan pada TOM20 namun tidak berpengaruh signifikan terhadap PGC-1α dan COX IV jaringan paru-paru; 5) Pemberian ekstrak daun Moringa oleifera berpengaruh signifikan terhadap IL-6 namun tidak berpengaruh signifikan terhadap NF-κB jaringan paru-paru; 6) Secara parsial, pemberian ekstrak daun Moringa oleifera tidak berpengaruh signifikan terhadap PGC-1α, TOM20, dan COX IV jaringan paru-paru. Namun ketika berinteraksi dengan aktivitas dan polusi, pemberian ekstrak daun Moringa oleifera berpengaruh signifikan terhadap TOM20 jaringan paru-paru. Penelitian ini berimplikasi dalam mendukung paradigma "Development Through Sport", menjadi dasar policy brief untuk meningkatkan kesadaran kualitas udara dan membantu pengembangan kurikulum dan program olahraga yang efektif. ABSTRACT The study was based on the importance of physical activity in open spaces as an effort to maintain and improve health. Activity in open spaces, especially in urban areas, has risks posed by air pollution. Antioxidant administration is expected to have an influence on inflammation and mitochondrial biogenesis of the lungs as a result of exposure to air pollution. The purpose of the study was to examine the difference in the effect of activity in open space and polluted open space as well as antioxidant administration on the inflammatory process and pulmonary mitochondrial biogenesis. The study used a quantitative approach with experimental methods and True Experimental design and Randomized Posttest-only Control Group Design. The research subjects used male Wistar rats aged 8-12 weeks. The results showed: 1) Activity has a significant effect on IL-6 but not significant on NF-κB of lung tissue; 2) Activity also has a significant effect on mitochondrial biogenesis biomakers PGC-1α and TOM20, but has no significant effect on COXIV; 3) Air pollution partially has no significant effect on IL-6 and NF-κB, but when interacting with the administration of Moringa oleifera leaf extract, pollution has a significant effect on IL-6 in pulmonary tissue; 4) Partially, pollution has a significant effect on TOM20 but has no significant effect on PGC-1α and COX IV in lung tissue; 5) The administration of Moringa oleifera leaf extract has a significant effect on IL-6 but no significant effect on NF-κB in lung tissue; 6) Partially, the administration of Moringa oleifera leaf extract has no significant effect on PGC-1α, TOM20, and COX IV in pulmonary tissue. However, when interacting with activity and pollution, the administration of Moringa oleifera leaf extract has a significant effect on TOM20 of lung tissue. This research has implications in supporting the "Development Through Sport" paradigm, informing policy briefs to raise air quality awareness and assisting the development of effective sports curricula and programs.
| Item Type: | Thesis (S3) |
|---|---|
| Additional Information: | https://scholar.google.com/citations?user=jFdX3GYAAAAJ&hl=en SINTA ID Ketua Promotor Amung Ma'mun: 5994366 SINTA ID Ko-Promotor Hamidie Ronald D Ray: 5978997 SINTA ID Anggota Promotor Beta Paramita: 258001 |
| Uncontrolled Keywords: | Aktivitas, Antioksidan, Inflamasi, Mitochondrial Biogenesis, Polusi, Paru-Paru, Ruang Terbuka Activity, Antioxidant, Inflammation, Lung Mitochondrial Biogenesis, Open Space, Pollutions |
| Subjects: | Q Science > QP Physiology |
| Divisions: | Sekolah Pasca Sarjana > Pendidikan Olahraga S-3 |
| Depositing User: | LUCKY ANGKAWIDJAJA RORING |
| Date Deposited: | 05 Oct 2024 16:08 |
| Last Modified: | 05 Oct 2024 16:08 |
| URI: | http://repository.upi.edu/id/eprint/126271 |
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