Alfiyah Nur Fadhilah, - (2024) ISOLASI DAN KARAKTERISASI SENYAWA TURUNAN FLAVONOID DARI KAYU BATANG CEMPEDAK (Artocarpus integer). S1 thesis, Universitas Pendidikan Indonesia.
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Abstract
Flavonoid merupakan turunan dari 2-fenil-benzo-γ-piron yang termasuk dalam keluarga besar senyawa polifenolik alami dengan tipe struktur C3-C6-C3. Salah satu sumber tanaman yang menghasilkan flavonoid yaitu famili Moraceae terutama genus Artocarpus dengan spesiesnya yaitu cempedak (Artocarpus integer). Beberapa literatur menunjukkan hasil isolasi flavonoid dari cempedak pada berbagai jaringan seperti akar, kulit akar, kulit batang, batang, dan inti kayu. Akan tetapi, masih sedikit yang melaporkan hasil isolasi flavonoid pada kayu batang cempedak. Penelitian ini bertujuan untuk melakukan isolasi dan karakterisasi senyawa turunan flavonoid dari kayu batang cempedak (Artocarpus integer). Metode isolasi dilakukan dalam beberapa tahap yaitu tahap ekstraksi, fraksinasi dan purifikasi. Tahap fraksinasi dan purifikasi dilakukan dengan teknik kromatografi cair vakum (KCV), kromatografi lapis tipis preparatif (KLT-P) dan kromatografi lapis tipis (KLT). Hasil penelitian menunjukkan fraksinasi dan purifikasi pada fraksi semipolar menghasilkan satu isolat yaitu isolat C.1.1 dengan 5 mg. Karakterisasi dilakukan dengan menggunakan spektrofotometer NMR (Nuclear Magnetic Resonance). Hasil dari karakterisasi menunjukkan senyawa isolat (1) memiliki struktur senyawa yang serupa dengan Artoindonesianin E-1. Flavonoids are derivatives of 2-phenyl-benzo-γ-pyrone which belong to a large family of natural polyphenolic compounds with C3-C6-C3 structure type. One of the plant sources that produce flavonoids is the Moraceae family, especially the genus Artocarpus with its species, cempedak (Artocarpus integer). Some literature shows the results of flavonoid isolation from cempedak in various tissues such as roots, root bark, stem bark, stems, and heartwood. However, there are still few reports on flavonoid isolation results in cempedak stem wood. This study aims to isolate and characterize flavonoid-derived compounds from cempedak (Artocarpus integer) stem wood. The isolation method was carried out in several stages, namely the extraction, fractionation, and purification stages. The fractionation and purification stages were carried out by vacuum liquid chromatography (VLC), preparative thin layer chromatography (TLC-P) and thin layer chromatography (TLC) techniques. The results showed that fractionation and purification of the semipolar fraction produced one isolate, namely isolate C.1.1 with 5 mg. Characterization was carried out using NMR (Nuclear Magnetic Resonance) spectrophotometer. The results of the characterization showed the isolate compound (1) has a similar compound structure with Artoindonesianin E-1.
| Item Type: | Thesis (S1) |
|---|---|
| Additional Information: | ID SINTA Dosen Pebimbing: Iqbal Musthapa : 0023127503 Heli Siti Halimatul Munawaroh : 5978104 |
| Uncontrolled Keywords: | Cempedak, Flavonoid, Isolasi, Karakterisasi, Isolation, Characterization, Flavonoid, Artocarpus integer |
| Subjects: | L Education > L Education (General) Q Science > QD Chemistry |
| Divisions: | Fakultas Pendidikan Matematika dan Ilmu Pengetahuan Alam > Jurusan Pendidikan Kimia > Program Studi Kimia (non kependidikan) |
| Depositing User: | Alfiyah Nur Fadhilah |
| Date Deposited: | 12 Sep 2024 08:40 |
| Last Modified: | 12 Sep 2024 08:40 |
| URI: | http://repository.upi.edu/id/eprint/123956 |
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